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. 1999 Apr 1;13(7):827–840. doi: 10.1101/gad.13.7.827

Table 2.

Summary of dE2F−and dDP−defects

Genotype
Mutant protein
Viability
Viability with reduced cyclin E dose
Eggshell morphology
Inappropriate genomic replication
Amplification (BrdU foci)
ORC2 foci
dE2F91 graphic file with name gad.9t2a.jpg − −a N.D. N.D. N.D. N.D.
DNALeucineActivation &
bindingzipperRb binding
dE2Fi1 graphic file with name gad.9t2b.jpg + −  thin no −/+b − 
DNALeucine
bindingzipper
dE2Fi2 graphic file with name gad.9t2c.jpg + +  thick no ++c + 
DNA
binding
dDPa1 graphic file with name gad.9t2d.jpg + N.D. very thin yes − −d
a

These animals die earlier in development with a twofold reduction of the zygotic cyclin E contribution. 

b

(−/+) Reduced, but not absent, levels of amplification. 

c

(++) Increased levels of amplification relative to wild type. 

d

Uniform nuclear ORC2 localization persists inappropriately.