Table 1. Selected genes and functions.

#SNPsa	Gene	Full Gene Name	Chr.	Array Findingsb	Reported Processes and Functionc	Reported Associated Diseases
9	KIF3A	kinesin family member 3A	5q31	Down	protein binding, ATP binding, microtubule motor activity, nucleotide binding
53	DNAH5	dynein, axonemal, heavy polypeptide 5	5p15	Down	microtubule motor activity, ATP binding, ATPase activity, nucleotide binding	primary ciliary dyskinesia, ciliary motility disorders
68	ADCY2	adenylate cyclase 2	5p15	Down	adenylate cyclase activity, magnesium ion binding, phosphorus-oxygen lyase activity
7	PLAU	plasminogen activator, urokinase	10q24	Up	kinase activity, peptidase activity, plasminogen activator activity, serine-type endopeptidase activity	acantholysis, alzheimers rheumatoid arthritis, cancer, endometriosis
53	PDE4B	phosphodiesterase 4B	1p31	Up	3′,5′-cyclic-AMP phosphodiesterase activity, 3′,5′-cyclic-nucleotide phosphodiesterase activity, catalytic activity, hydrolase activity	chronic kidney failure, schizophrenia
4	SPRR2B	small proline-rich protein 2B	1q21	Up	structural molecule activity, keratinization

^aIndicates the total number of genotyped SNPs.

^bIndicates the direction of gene expression of uncontrolled asthmatics versus non-allergic controls.

^cObtained from Gene Ontology website (www.geneontology.org).