Table 2. Inclusion criteria of discovery and replication study populations.

Population	Race or Ethnicity	Population Source(s)	# asthmatics	# allergic	# controls	Determination of race or ethnicity	Asthma inclusion criteria	Allergic inclusion criteria	Control inclusion criteria
Discovery	Caucasian	Greater Cincinnati Pediatric Clinic Repository (GCPCR), CCHMC Genomic Control Cohort (GCC)	312	220	246	Race was self-reported and ascertained by questionnaire; both the participant and his/her parents must have been identified themselves as Caucasian/White; all subjects were non-Hispanic	Children 4–17 years old with confirmed physician diagnoses of asthma based on clinical examination, available pulmonary function test results and respiratory symptom scores at a CCHMC-based specialty clinic	Non-asthmatic children ages 4–17 years old with physician diagnosed allergic rhinitis or atopic dermatitis based on radioallergosorbent testing or skin prick allergy testing; or children with a personal history of either environmental allergies, hay fever or eczema	Non-allergic Caucasian controls were those children ages 4–17 years old that did not meet the criteria to be either an asthmatic or allergic case, had no personal history of food allergies and no family history (parents and siblings) of asthma
Replication	African-American	GCPCR, GCC	182	129	39	Race was self-reported and ascertained by vquestionnaire; both the participant and his/her parents must have been identified themselves as African American/Black; all subjects were non-Hispanic	See Discovery Caucasian population above	See Discovery Caucasian population above	See Discovery Caucasian population above
	Caucasian	GCC, Cincinnati Control Cohort (CCC)	74	NAa	211	Parents of asthmatics reported their children to be Caucasian by questionnaire; adult controls similarly reported their race to be Caucasian by questionnaire	Caucasian children ages 4 to 18 years with parent-reported asthma from a population-based representative sample from Greater Cincinnati	NA	Caucasian adults ages 24 to 90 years with no personal or family history of asthma (as determined by self-report) from a population-based representative sample from Greater Cincinnati
	Puerto Rican	Genetics of Asthma in Latino Americans (GALA) Study	398	NA	712	Ethnicity was self-reported and ascertained by questions; both biological parents and all biological grandparents of asthmatics had to be identified as being of Puerto Rican ethnicity	Index children at least 8 years of age with physician diagnosed asthma (confirmed by hospital-based medical chart review) and two or more parent-reported asthma symptoms (among wheezing, coughing, and shortness of breath) in the last 2 years were enrolled over a 4-year period in the San Francisco Bay Area, California, New York City, New York , Puerto Rico, and Mexico City, Mexico	NA	One or both biological parents of index asthmatic children were enrolled; allergic status was not a criteria for inclusion or exclusion
	Mexican	GALA	300	NA	585	Ethnicity was self-reported and ascertained by questionnaire; both biological parents of asthmatic children and all biological grandparents had to be identified as being of Mexican ethnicity	See Puerto Rican population above	NA	See Puerto Rican population above

^aNot applicable.