. 2011 Aug 30;6(8):e23714. doi: 10.1371/journal.pone.0023714

Table 4. KIF3A SNP associations with asthma.

Population =			Discovery Caucasian^a		African-American^a		Secondary Caucasian^b		Puerto Rican^c	Mexican^c
# cases/# controls =			312/246		182/39		74/211		398	300
KIF3A SNP	Major/Minor Allele	F_ST ^e	OR	P-value	OR	P-value	OR	P-value	P-value	P-value
rs12186803	G/A	0.33	2.08	0.00011	1.79	0.032	3.21	0.005
rs1080001	A/G	0.32	2.08	0.00009	1.83	0.029	2.76	0.011
rs7737031	C/T	0.34	2.18	0.00003	1.83	0.028	2.76	0.011	0.0458	0.471
rs9784675	A/G^d	0.33	2.09	0.00007	1.61	0.064	3.32	0.002
rs3798130	G/A^d	0.33	2.16	0.00004	1.56	0.086	3.21	0.005
rs2299011	C/G^d	0.32	2.19	0.00003	1.52	0.101	3.21	0.005
rs12514685	C/T^d	0.32	2.16	0.00004	1.52	0.100	2.76	0.011
rs1468216	G/A	0.01	0.78	0.16870	0.68	0.191	1.08	0.810
rs17691077	A/C	0.06	0.85	0.41000	-	-	-	-

The discovery Caucasian population and African American population consisted of asthmatic children from the GCPCR and non-asthmatic/non-allergic controls from the GCPCR and GCC. Associations between asthmatics and controls were tested using an additive model. Odds ratios (OR) were determined using logistic regression based on the minor allele after adjusting for age, gender and population stratification. Bolding indicates the SNP associations <0.05. 7 of 9 SNPs were significant even after considering multiple comparisons (p<0.0006).

The Secondary Caucasian population consisted of asthmatic children from the GCC and non-asthmatic adult controls from the CCC. OR and p-values were determined using HapMap CEU results (release 22) and Affymetrix data from each cohort for imputation analysis.

The Puerto Rican and Mexican populations consisted of mother, father, child trios enrolled in the GALA Study. The value provided is the frequency of childhood asthmatics within those trios.

Major and minor alleles are reversed in African Americans;

Value of fixation index (F_ST) between CHB (China/Beijing) and CEU (Caucasian Europe, as represented by Utah) HapMap populations.