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. 2011 May 23;96(9):1318–1326. doi: 10.3324/haematol.2011.041053

Figure 4.

Figure 4.

Experiments confirming the synergistic effect of CCND3 or NRAS with Bcl2 and Myc. (A) In vitro growth curves of various stable integrants in the absence of IL-7 and ST-2 cells. Data are the mean ± s.e.m. (triplicate). (B) Methylcellulose colony-forming abilities of various stable integrants. Data are the mean ± s.e.m. (triplicate). P values are two-sided (Student’s t test). (C) Photograph of representative colonies of various integrants in the first plating. Scale bar represents 10 mm. (D-G) Kaplan-Meier survival curves of SCID mice transplanted with various stable integrants. “3 genes” (n=9) in (D) indicates Bcl2/Myc/CCND3 (n=3), CCND3/Myc/Bcl2 (n=3) and Bcl2/CCND3/Myc (n=3). “2 genes” (n=7) in (D) indicates Bcl2/Myc/mock (n=3), CCND3/Myc/mock (n=2) and Bcl2/CCND3/mock (n=2).