Table 3. Demographics and distribution of parameters that are known to affect graft and patient survival after kidney transplantation.
Demographics | Absence of HLA-C2(n = 303) | Presence of HLA-C2(n = 457) | P value |
Recipient age | 43.0 (CI 41.2–44.8) | 42.3 (CI 40.9–43.6) | 0.49* |
Donor age | 43.5 (CI 41.6–45.4) | 43.5 (CI 42.1–44.9) | 0.96* |
Recipient sex M∶F | 191∶112 | 278∶179 | 0.55+ |
Donor sex M∶F | 180∶123 | 236∶221 | 0.03+ |
Seropositive CMV in recipient | 169 | 240 | 0.43+ |
Seropositive CMV in donor | 150 | 212 | 0.41+ |
Type of transplant; Deceased donor: Live donor | 258∶45 | 382∶75 | 0.60+ |
Number of transplant | |||
1 | 256 | 398 | 0.26+ |
2 | 39 | 47 | |
3 | 8 | 12 | |
Acute Rejection | 86 | 129 | 0.96+ |
Type of CNI; Cyclosporin: Tacrolimus | 290∶15 | 434∶21 | 0.90+ |
Anti-CD25 monoclonal antibody | 50 | 82 | 0.59+ |
HLA mismatch (no. of antigens) | |||
0 | 44 | 58 | 0.62+ |
1 | 31 | 41 | |
2 | 128 | 206 | |
3 | 71 | 108 | |
4 | 15 | 25 | |
5 | 10 | 14 | |
6 | 4 | 5 | |
Mean mismatches per patient | 2.09 | 2.15 | |
DR locus mismatch (no. of antigens) | |||
0 | 207 | 297 | 0.42+ |
1 | 83 | 142 | |
2 | 13 | 18 | |
Mean mismatches per patient | 0.36 | 0.41 |
As the analysis involved the comparison between absence of HLA-C2 in the recipient versus presence of HLA-C2 in the recipient groups were divided accordingly. Absence of HLA-C2 represents HLA-C1 homozygous whereas presence of HLA-C2 combines both heterozygous and HLA-C2 homozygous groups. CI is 95% confidence interval.
*indicates significance by ANOVA test,
indicates significance by Kendall's tau-b test.