Table 2.
GCM1 maternal and fetal genotypes and risk of PIH
| GCM1 locus | Maternal | Fetal | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | OR (95% Cl) | OR (95% Cl) | OR (95% Cl) | N (%) | OR (95% Cl) | OR (95% Cl) | OR (95% Cl) | |||
| Controls | Cases | Unadjusted | Adjusted* | Adjusted** | Controls | Cases | Unadjusted | Adjusted* | Adjusted** | |
| rs13200319 | ||||||||||
| CC | 139 (85%) | 116 (89%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 139 (85%) | 117 (90%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| CT | 22(14%) | 13 (10%) | 0.70 | 0.63 | 0.83 | 22(14%) | 13 (10%) | 0.62 | 0.63 | 0.71 |
| [0.35, 1.41] | [0.31, 1.28] | [0.40, 1.65) | [0.31, 1.22] | [0.31, 1.32] | [0.30, 1.41] | |||||
| TT | 2 (1%) | 1 (2%) | 2 (1%) | 0 (0%) | ||||||
| Trend | 0.72 | 0.65 | 0.89 | 0.64 | 0.61 | 0.66 | ||||
| [0.31, 1.37] | [0.34, 1.25] | [0.44, 1.64] | [0.31, 1.32] | [0.31, 1.21] | [0.30, 1.26] | |||||
| rs9349655 | ||||||||||
| GG | 144 (88%) | 114 (89%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 137 (84%) | 117 (91%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| GC | 20(12%) | 10 (8%) | 0.88 | 0.86 | 0.94 | 23(14%) | 11 (9%) | 0.48 | 0.45 | 0.54 |
| [0.43, 1.83] | [0.41, 1.80] | [0.47, 1.71] | [0.23, 1.00] | [0.21, 0.97] | [0.24, 0.98] | |||||
| CC | 0 (0%) | 4 (3%) | 4 (2%) | 0 (0%) | ||||||
| Trend | 1.14 | 1.13 | 1.31 | 0.47 | 0.44 | 0.45 | ||||
| [0.62, 2.11] | [0.60, 2.11] | [0.63, 2.31] | [0.23, 0.92] | [0.22, 0.90] | [0.22, 0.78] | |||||
| rs2816345 | ||||||||||
| AA | 121 (73%) | 92 (69%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 112 (68%) | 96 (72%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| AG | 39 (24%) | 34 (24%) | 1.15 | 1.09 | 1.02 | 47 (28%) | 37 (28%) | 0.92 | 0.93 | 0.84 |
| [0.67, 1.96] | [0.63, 1.87] | [0.59, 1.61] | [0.55, 1.53] | [0.55, 1.56] | [0.50, 1.40] | |||||
| GG | 5 (3%) | 8 (6%) | 2.10 | 2.30 | 2.94 | 6 (4%) | 1 (1%) | 0.19 | 0.16 | 0.16 |
| [0.67, 6.64] | [0.71, 7.47] | [0.76, 8.25] | [0.02, 1.64] | [0.02, 1.36] | [0.00, 0.58] | |||||
| Trend | 1.28 | 1.27 | 1.23 | 0.78 | 0.76 | 0.75 | ||||
| [0.85, 1.93] | [0.83, 1.93] | [0.80, 1.91] | [0.50, 1.22] | [0.48, 1.20] | [0.48, 1.14] | |||||
| rs2518573 | ||||||||||
| GG | 109 (66%) | 89 (66%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 104(63%) | 92 (69%) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| GT | 49 (30%) | 38 (29%) | 0.95 | 0.94 | 0.93 | 54 (33%) | 40 (30%) | 0.84 | 0.87 | 0.78 |
| [0.57, 1.58] | [0.56, 1.58] | [0.59, 1.41] | [0.51, 1.37] | [0.53, 1.45] | [0.47, 1.23] | |||||
| TT | 6 (4%) | 7 (5%) | 1.43 | 1.49 | 2.06 | 6 (4%) | 2 (1%) | 0.38 | 0.30 | 0.34 |
| [0.46, 4.41] | [0.47, 4.71] | [0.60, 5.35] | [0.07, 1.31] | [0.06, 1.60] | [0.00, 1.26] | |||||
| Trend | 1.05 | 1.05 | 1.1 | 0.77 | 0.77 | 0.75 | ||||
| [0.70, 1.57] | [0.70, 1.59] | [0.73, 1.59] | [0.50, 1.19] | [0.50, 1.19] | [0.48, 1.06] | |||||
*
Adjusted for parity (nulliparous yes/no) and maternal age (<20, 20-32, >32) by logistic regression
**
Adjusted for fetal (or maternal) genotype at the same locus (LEM method)