Table 3.

GCM1 fetal genotypes and risk of PIH (multilocus and parity adjusted)

GCM1	Locus Odds Ratios and 95% Confidence Intervals†
	Single Locus	Multilocus Adjusted
		Model 1*	Model 2**	Model 3***	Model 4****	Model 5*****
rs13200319
nT (trend)	0.65 (0.33, 1.27)	0.60 (0.30, 1.19)			0.59 (0.30, 1.19)	0.58 (0.28, 1.17)
rs9349655
nC (trend)	0.49 (0.24, 0.97)	0.46 (0.23, 0.93)	0.48 (0.21, 1.12)	0.50 (0.22, 1.12)	0.45 (0.20, 1.02)	0.42 (0.18, 0.99)
rs2816345
nG (trend)	0.74(0.47, 1.18)		1.00 (0.56, 1.78)			1.13 (0.62, 2.07)
rs2518573
nT (trend)	0.75(0.48, 1.16)			0.97 (0.57, 1.64)	1.05 (0.61, 1.81)

^*rs13200319 and rs9349655 mutually adjusted

^**rs9349655 and rs2816345 mutually adjusted

^***rs9349655 and rs2518573 mutually adjusted

^****rs13200319, rs9349655 and 2518573 mutually adjusted

^*****rs13200319, rs9349655, and rs2816345 mutually adjusted

^†includes subjects (129 cases & 160 controls) for whom all 4 fetal genotypes are not missing; adjusted for parity (nulliparous yes/no) and maternal age (<20, 20-32, >32) by logistic regression

Note: SNPs which are highly correlated (rs2816345 and rs2518573 cannot be included in the same model.