Table 1.
Clinical and demographic characteristics among all DLBCL patients and by DLBCL molecular subtype*
| DLBCL patients in the present analysis | ||||
|---|---|---|---|---|
| All DLBCL patients | Total | GCB-DLBCL | Non-GCB-DLBCL | |
| Characteristic | N (%) | N (%) | N (%) | N (%) |
| Total | 417 (100.0) | 214 (100.0) | 112 (100.0) | 102 (100.0) |
| Age at DLBCL diagnosis | ||||
| <45 years | 96 (23.0) | 45 (21.0) | 22 (19.6) | 23 (22.5) |
| 45-64 | 196(47.0) | 96 (44.9) | 52 (46.4) | 44 (43.1) |
| 65+ | 125 (30.0) | 73(34.1) | 38 (33.9) | 35 (34.3) |
| Sex | ||||
| Male | 236 (56.6) | 125 (58.4) | 68 (60.7) | 57 (55.6) |
| Female | 181 (43.4) | 89 (41.6) | 44 (39.3) | 45 (44.1) |
| Race | ||||
| White | 360 (86.3) | 186 (86.9) | 97 (86.6) | 89 (87.3) |
| Non-white | 57 (13.7) | 28(13.1) | 15 (13.4) | 13 (12.7) |
| Education | ||||
| <12 years | 42(10.1) | 24 (11.2) | 11 (9.8) | 13 (12.7) |
| 12-15 | 250(60.1) | 129 (60.3) | 67 (59.8) | 62 (60.8) |
| 16+ | 124 (29.8) | 61(28.5) | 34 (30.4) | 27 (26.5) |
| Study center | ||||
| Detroit | 100 (24.0) | 37 (17.3) | 23 (20.5) | 14 (13.7) |
| Iowa | 119 (28.5) | 81(37.9) | 39 (34.8) | 42 (41.2) |
| Los Angeles | 99(23.7) | 43(20.1) | 24 (21.4) | 19 (18.6) |
| Seattle | 99(23.7) | 53 (24.8) | 26 (23.2) | 27 (26.5) |
| B-symptoms | ||||
| No | 148 (35.5) | 90(42.1) | 47 (42.0) | 43 (42.2) |
| Yes | 112 (26.9) | 60 (28.0) | 29 (25.9) | 31 (30.4) |
| Unknown | 157 (37.6) | 64 (29.9) | 36 (32.1) | 28 (27.5) |
| Stage | ||||
| Local | 137 (32.9) | 70(32.7) | 39 (34.8) | 31 (30.4) |
| Regional | 96 (23.0) | 56 (26.2) | 27 (24.1) | 29 (28.4) |
| Distant | 164 (39.3) | 83 (38.8) | 44 (39.3) | 39 (38.2) |
| Unknown | 20 (4.8) | 5 (2.3) | 2 (1.8) | 3 (2.9) |
| Initial chemotherapy | ||||
| No | 55 (13.2) | 29 (13.6) | 18 (16.1) | 11 (10.8) |
| Yes | 355(85.1) | 185 (86.4) | 94 (83.9) | 91 (89.2) |
| Unknown | 7(1.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| t(14;18) translocation | ||||
| Negative | 120 (28.8) | 120(56.1) | 56 (50.0) | 64 (62.7) |
| Positive | 92(22.1) | 92 (43.0) | 55 (49.1) | 28 (36.3) |
| Unknown | 205 (49.2) | 2 (0.9) | 1 (0.9) | 1 (1.0) |
Abbreviations: diffuse large B-cell lymphoma (DLBCL), germinal center B-cell (GCB).
*
DLBCL molecular subtype assigned using Hans et al.[7] (GCB-DLBCL: CD10+ or CD10-/BCL6+/MUM1-).