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Target recognition by a typical miRNA. (A) A given miRNA may have several targets in an mRNA which could be masked by an RNA stemloop structure or by RNA-binding proteins. (B) Three target sequences of the human miRNA let-7a are shown in the 3'UTR of H-Ras mRNA [2]. Note the partial and differing level of sequence complementarity between the miRNA and its target sites. Note that in RNA the base T is represented by U (uracil) and that G can base pair with U.
