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. 2011 Aug 30;6(8):e24147. doi: 10.1371/journal.pone.0024147

Figure 7. Induction of CS protein specific antibody responses by Ad-CSP vaccines augmented by rEA or EAT-2.

Figure 7

Total IgG antibody against CS protein is ablated in Ad-CSP+Ad-GFP/rEA co-vaccinated mice while Ad-CSP+Ad-EAT2 co-vaccinated mice demonstrated significantly more CS protein specific IgG than naïve animals. BALB/cJ mice (n = 5) were co-injected IM with 5×107 vps/mouse of Ad-CSP and 5×107 vps/mouse of Ad-GFP or 5×107 vps/mouse of Ad-CSP and 5×107 vps/mouse of either (A) Ad-GFP/rEA or (B) Ad-EAT2. Plasma was collected at day 14. Total IgG against CS protein in the plasma was measured by ELISA. The bars represent mean ± SD. Statistical analysis was completed using One Way ANOVA with a Student-Newman-Keuls post-hoc test, * Denotes significance over naïve p<0.05. † Denotes significant difference between treatments p<0.05.