Figure 2. Rescue of antibiotic delayed death and apicoplast genome loss.
(A) Survival of parasites over 4 life cycles treated with (1) doxycyline only, (2) doxycycline+IPP, or (3) doxycycline+IPP for three cycles followed by removal of both. Parasitemia is normalized to that of an untreated control. (B) Apicoplast∶nuclear and (C) mitochondria∶nuclear genome ratio of doxycycline only and doxycycline+IPP treated parasites over the same time course. Genome ratios are normalized to an untreated control. Data from three separate passages are shown.