FIG. 8.

Ischemia-induced inflammation enhances mucosal netrin-1 production. During ischemia-elicited inflammation (e.g., during intestinal ischemia), HIF is stabilized and coordinates the transcriptional induction of netrin-1. As such, epithelial-released netrin-1 can attenuate neutrophil accumulation into the ischemic intestine. This process involves enhancement of adenosine signals through the A2BAR. (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars).