. 2011 Oct 15;15(8):2095–2107. doi: 10.1089/ars.2010.3877

Table 1.

Metabolite Levels in 12 Month-Old Spinal Cord from Abcd1⁻ Mice

Metabolite	Enzymes	Values (mean±SD)	Fold change (Wt vs. Abcd1⁻)	p-Value
Fructose 1,6 bisphosphate	Aldolase^a	Wt=52776±16221 Abcd1⁻=47710±8971	−10%	n.s.
DHAP/GA3P	Aldolase^a	Wt=178258±87111 Abcd1⁻=74938±44601	−58%	<0.05
2(or 3)-phosphoglycerate	Phosphoglycerate kinase^a	Wt=11533±4149 Abcd1⁻=5658±1460	−51%	=0.01
Pyruvate	Pyruvate kinase^a Dihydrolipoamide dehydrogenase^a (Pyruvate dehydrogenase complex)	Wt=403616±132627 Abcd1⁻=462663±69665	+14%	n.s.
Lactate	Lactate dehydrogenase	Wt=6253±583 Abcd1⁻=6742±539	+8%	n.s.
Oxaloacetate	Citrate synthase	Wt=11160±3668 Abcd1⁻=11689±3076	+4%	n.s.
Citrate	Aconitase^a	Wt=6592±1799 Abcd1⁻=9747±1724	+47%	=0.02
α-Ketoglutarate	Dihydrolipoamide dehydrogenase^a (α-ketoglutarate dehydrogenase complex)	Wt=76446±3633 Abcd1⁻=92223±10805	+20%	=0.01
Fumarate	Fumarase	Wt=16860±2531 Abcd1⁻=18587±5114	+10%	n.s.
Malate	Malate dehydrogenase	Wt=70599±11146 Abcd1⁻=64810±17845	−8%	n.s.

Fructose 1–6 bisphosphate, dihydroxyacetone phosphate and glyceraldehyde 3 phosphate (GA3P), 2 and 3-phosphoglycerate, pyruvate, lactate, oxalacetate, citrate, α-ketoglutarate, fumarate, and malate levels were quantified in Wt and Abcd1⁻ mice.

^{^a}

Oxidized.

n.s. not significant.