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. Author manuscript; available in PMC: 2012 Feb 19.
Published in final edited form as: Cell. 2011 Aug 19;146(4):621–632. doi: 10.1016/j.cell.2011.06.048

Figure 3. Similar architectures of type I IFN complexes are distinct from type II and type III IFN receptor complexes.

Figure 3

(A) The IFN molecules of the IFNω and IFNα2(YNS) ternary complexes were superimposed and are shown in side view and top view. The RMSD for the overall superposition of both structures is 0.9 Å. (B) The IFNω ternary complex is shown side-by-side with the IFNγ-(IFNGR1)2 complex (PDB accession code: 1FG9), and the IFNλ-IFNLR1 complex (PDB accession code: 3OG6). (N, C: amino- and carboxy-termini. SD1–SD4: subdomains of IFNAR1; D1, D2: N- and C-terminal domain of IFNAR2. See also Figure S3B.