Table 2.
Distribution of IL12B 3' UTR genotypes in children with P. falciparum malaria
| IL12B 3' UTR Genotypes | Non-SMA | SMA | Pa |
|---|---|---|---|
| No. of participants, n | 304 | 240 | |
| AA | 132 (43.4) | 82 (34.2) | |
| AC | 123 (40.5) | 104 (43.3) | 0.048 |
| CC | 49 (16.1) | 54 (22.5) | |
| P(A) = 0.64 | P(A) = 0.56 |
Data are presented as proportion of individuals [n (%)] within non-SMA and SMA groups. Children with P. falciparum malaria (n = 544) were categorized according to SMA status based on age- and geographically-appropriate Hb concentrations [i.e., Hb<6.0 g/dL, with any density parasitaemia) [4]] and non-SMA (Hb≥6.0 g/dL, with any density parasitaemia). aStatistical significance determined by Chi-square analysis. The overall distribution of genotypes between the non-SMA and SMA groups was statistically significant (χ2 test, P = 0.048).