Figure 2. Reversion of spatial association of gene expression in aging tissue under the anti-aging intervention of caloric restriction or resveratrol treatment (p<0.01).

The gene with expression alterations from 18 to 27 months in liver (L), muscle (M), adipose (A) and heart (H) from mice fed a standard diet with a low dose of resveratrol (SDLR) or a standard diet with high resveratrol (SDHR) showed significant restoration of spatial association compared to two reference groups of mice without anti-aging interventions fed a standard diet (SD) ad libitum or a high-calorie diet (HC) ad libitum, losing spatial association at 27 months. Similar restoration occurred in calorie-restricted mouse groups subjected to every-other-day feeding (EOD), every-other-day feeding with low resveratrol (EODLR), or every-other-day feeding with high resveratrol (EODHR).