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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Exp Biol Med (Maywood). 2011 Jul 12;236(9):1051–1063. doi: 10.1258/ebm.2011.010400

Figure 3. Attenuation of endoplasmic reticulum (ER) stress by dietary wolfberry in db/db type 2 diabetic mice.

Figure 3

After dietary treatments, animals were euthanized. The whole retina was isolated and subjected to Western blot. Representative images were shown (A). β-actin was used as an euqal loading control to normalize each protein expression. Relative band intensity of each protein to β-actin was used for graphing and statistic analysis. n=21. In all cases, the statistic significance at p≤ 0.05 was marked by different letters a,b, and/or c. CD, control diet; WD, control diet with 1 % (kCal) wolfberry. BiP, binding immunoglobulin protein (also named as glucose regulated protein 78, GRP78); PERK, protein kinase RNA-like ER kinase; ATF6, activating transcription factor -6; IB, immunoblot. A. Representative images; B, BiP; C, PERK; D, ATF6; E, active caspase-12; F, active caspase-3.