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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Exp Biol Med (Maywood). 2011 Jul 12;236(9):1051–1063. doi: 10.1258/ebm.2011.010400

Figure 4. Wolfberry restores AMPK, FOXO3α, and antioxidant enzymes thioredoxin and Mn SOD in retina of db/db type 2 diabetic mice.

Figure 4

Whole retina was isolated and subjected to Western blot at study termination. Representative images were shown (A). β-actin was used as an equal loading control to normalize each protein expression. Relative band intensity of each protein to β-actin was used for graphing and statistic analysis. n=21. The statistic significance at p≤ 0.05 was marked by different letters a,b, and/or c. CD, control diet; WD, control diet with 1 % (kCal) wolfberry. AMPKα, AMP activated protein kinase α; Mn SOD, Mn superoxide dismutase; FOXO3α, Forkhead O transcription factor O 3α. B, phospho-AMPKα Thr172; C, AMPKα; D, thioredoxin; E, Mn SOD; F, phospho-FOXO3α Ser253; G, FOXO3α