SynGAP, but not PSD-95, moves out of the PSD core upon depolarization. Histograms from representative experiments showing the distribution of label for SynGAP (A) and PSD-95 (B) under control (black bars) and depolarizing conditions (gray bars). The vertical line denotes the boundary between the PSD core and the contiguous network. Upon depolarization, distribution of SynGAP label shifts to the contiguous network (P < 0.0001, Wilcoxin-Mann-Whitney rank sum test), while the distribution of PSD-95 label remains unchanged.