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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Pediatr Res. 2011 Oct;70(4):332–338. doi: 10.1203/PDR.0b013e3182294471

Table 2. Effect of ductus treatment on VCAM-1 expression and mononuclear cell adhesion to the ductus lumen (immunohistochemistry).

The number of endothelial cells lining the ductus lumen that are positive for VCAM-1, and the number of VLA-4, CD163, CD14, or CD8 positive mononuclear cells that adhere to the ductus luminal wall, are expressed per 100 lumen-lining cells.

Positive expressing cells/100 luminal cells
Fetus Newborn
Control		 Newborn
Anti-VLA-4		 Newborn
Anti-VEGF
(N=7) (N=14) (N=7) (N=6)
VCAM-1 0±0 4±4* 3±4* 4±4*
VLA-4 0±0 4±2* NA 0±0†
CD163 0±0 7±4* 2±2† 0±1†
CD14 0±0 6±4* 2±2† 1±1†
CD8 0±0 7±5* 4±3* 4±3*
*

p < 0.05 vs fetal ductus;

†

p < 0.05 vs newborn control ductus.

N, number of ductus examined. NA, tissue could not be examined because the monocyte VLA-4 receptors were already saturated with the HP1/2 anti-VLA-4 MAb.