Table 1.

Longitudinal rCBV Dataset in CBKO Mice.

ROI	Variable	Estimated β	Standard error	Wald Chi-Square	Significance
Entorhinal Cortex	Genotype	0.061	0.032	3.66	0.063
	Time	0.001	0.002	0.25	0.616
	Genotype × Time	−0.010	0.003	3.86	0.053
CA1 subfield	Genotype	0.004	0.023	5.16	0.023*
	Time	0.002	0.026	0.02	0.877
	Genotype × Time	−0.004	0.003	1.26	0.261
CA3 subfield	Genotype	0.037	0.030	1.48	0.223
	Time	0.000	0.002	2.92	0.087
	Genotype × Time	−0.006	0.003	3.47	0.062
Dentate gyrus	Genotype	0.027	0.022	1.44	0.229
	Time	0.001	0.002	2.10	0.147
	Genotype × Time	−0.007	0.002	6.15	0.013*
Subiculum	Genotype	0.064	0.031	4.13	0.052
	Time	0.004	0.003	0.05	0.824
	Genotype ×Time	−0.010	0.005	3.70	0.054

Genotype represents CBKO mice vs. age matched controls

Time represents the repeated measurements

Genotype × Time is the interaction term representing age dependency of the changes.

^*denotes statically significant difference p ≤ 0.05.