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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Brain Behav Immun. 2011 Apr 23;25(7):1408–1415. doi: 10.1016/j.bbi.2011.04.013

Figure 4.

Figure 4

Intrathecal administration of 1 μg LPS + prior administration of subcutaneous CORT (2.5 mg/kg) or vehicle. IL-1ra (100 μg in 1 μl) or equivolume vehicle was coadministered intrathecally with the LPS. Mechanical sensitivity was tested using the von Frey test, before (baseline, BL) CORT or vehicle, before (0) and 1–24 h after intrathecal administration. Time is reflected as post intrathecal administration. Solid circle depicts CORT+LPS+vehicle(n= 6), black squares depict vehicle+LPS+IL-1ra (n=6) and open circles depicts CORT+LPS+IL-1ra (n= 6). Data are presented as average absolute thresholds of left and right hind paws (mean ± SEM).

***P< 0.001, against CORT+LPS+vehicle.