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Percentage of synapses labeled for ER-α in the rat CA1 and NHP dlPFC in the context of age and estrogen status. Unlike levels in the rat hippocampus (p < 0.0001 for both aged groups), ER-α levels in the monkey dlPFC do not decline with age (p > 0.05). (Y = young, A = aged, E = estrogen-treated, V = vehicle-treated; adapted from Adams et al., 2002 and Wang et al., 2010)
