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Schematic representation of Cbfa1 function during and after embryonic development. (A) During embryogenesis Cbfa1 controls differentiation of a mesenchymal progenitor cell toward the osteoblastic lineage. (B) After birth, in fully differentiated osteoblasts, Cbfa1 controls the rate of bone formation by regulating directly the expression of the bone ECM-encoding genes. Moreover, Cbfa1 regulates its own gene expression.
