TABLE 1.
Demographic, clinicopathological, and treatment characteristics of 208 patients who underwent R0 resection for PDAC; stratified based on the presence or absence of PanIN in the transection margin
| All patients (N = 208) (%) |
Normal margin (n = 101; 48.6%) (%) |
PanIN at margin (n = 107; 51.4%) (%) |
P value | |
|---|---|---|---|---|
| Median age (years) [IQR] | 66 (59–74) | 65 (57–73) | 68 (60–74) | 0.21 |
| Race | ||||
| Caucasian | 179 (86.1) | 86 (85.1) | 93 (86.9) | 0.43 |
| Gender | ||||
| Male | 106 (51) | 57 (56.4) | 49 (45.8) | 0.13 |
| Female | 102 (49) | 44 (43.6) | 58 (54.2) | |
| Surgery | ||||
| Pylorus preserving Whipple | 124 (59.6) | 59 (58.4) | 65 (60.8) | 0.47 |
| Classic Whipple | 57 (27.4) | 31 (30.7) | 26 (24.3) | |
| Distal pancreatectomy | 27 (13) | 11 (10.9) | 16 (15) | |
| Median size (cm) [IQR] | 3 (2.5–4) | 3 (2–4) | 3 (2.5–4) | 0.21 |
| T classification | ||||
| T1 | 12 (6.9) | 6 (7) | 6 (6.9) | 0.28 |
| T2 | 33 (19.1) | 11 (12.8) | 22 (25.3) | |
| T3 | 125 (72.3) | 67 (77.9) | 58 (66.7) | |
| T4 | 3 (1.7) | 2 (2.3) | 1 (1.1) | |
| Lymph node metastases | ||||
| N0 | 50 (24) | 23 (22.8) | 27 (25.2) | 0.87 |
| N1a | 32 (15.4) | 15 (14.9) | 17 (15.9) | |
| N1b | 126 (60.6) | 63 (62.4) | 63 (58.9) | |
| Histologic grade | ||||
| G1 | 9 (4.3) | 5 (5) | 4 (3.7) | 0.58 |
| G2 | 117 (56.3) | 59 (58.4) | 58 (54.2) | |
| G3 | 81 (38.9) | 36 (35.6) | 45 (42.1) | |
| G4 | 1 (0.5) | 1 (1) | 0 (0) | |
| Venous invasion | ||||
| Present | 99 (47.6) | 47 (46.5) | 52 (48.6) | 0.94 |
| Lymphatic invasion | ||||
| Present | 35 (16.8) | 15 (14.9) | 20 (18.7) | 0.76 |
| Perineural invasion | ||||
| Present | 187 (89.9) | 92 (91.1) | 95 (88.8) | 0.85 |