Figure 6.

Families of the plots obtained with the multi-time, graphical method of Patlak in a 3S2X model with the ordinate equal to $\frac{(1-\text{Hct})\mathrm{\Delta }{\text{R}}_{1\text{t}}}{\mathrm{\Delta }{\text{R}}_{1\text{b}}}$ and the abscissa equal to the efflux-corrected term $\frac{\underset{0}{\overset{\text{t}}{\int }}{\text{e}}^{-{\text{k}}_{\text{b}}(\text{t}-\tau )}\mathrm{\Delta }{\text{R}}_{1\text{b}}(\tau )\text{d}\tau }{\mathrm{\Delta }{\text{R}}_{1\text{b}}}$, which is often referred to as ‘stretch time’ when the CA is injected as a bolus. 6A: With K^trans = 0.01, 0.005, and 0.00125 min⁻¹; top to bottom) and u_b = 0.02. 6B: With blood water fractions, u_b, set as 0.06, 0.04, and 0.01 (top to bottom) and K^trans = 4 × 10⁻³ min⁻¹. 6C: With the transendothelial rate of influx, k_be, varied from 10 to 2 to 0.5 s⁻¹(top to bottom), K^trans = 5 × 10⁻³ min⁻¹, and u_b = 0.05. 6D: Rate of exchange across parenchymal cell membrane set at either 10, 2, or 0.5 s⁻¹ (top to bottom), K^trans = 3 × 10⁻³ min⁻¹, and u_b = 0.03. The other parameters of this modeling are listed in Table 1.