Figure 5.
Levels of PrPC do not correlate with human PrP 129 polymorphism in AD patients. Levels of PrPC were measured by densitometry. For each sample, levels of actin were also assessed. Each PrP value was normalized to its actin value. These values were compared among individuals with various PRNP genotypes (M/M, M/V, V/V). (A–C) represent the data analyzed with 6H4; (D–F) represent the data analyzed with 3F4. Three brain regions including the frontal (A and D) and temporal (B and E) cortices and hippocampus (C and F) were analyzed.