Skip to main content
. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: Clin Chem. 2009 Mar 26;55(6):1177–1187. doi: 10.1373/clinchem.2008.113712

Table 3.

Second trimester, third trimester, and postpartum BUP-Gluc:NBUP-Gluc and NBUP:NBUP-Gluc ratios in urine specimens containing both analytes.

Participant BUP-Gluc:NBUP-Gluc NBUP:NBUP-Gluc
n Mean (SD) Median Range RSD,a % n Mean (SD) Median Range RSD, %
Ab
    Second trimester 6 0.05 (0.01) 0.05 0.04–0.07 20.8 4 0.08 (0.03) 0.08 0.06–0.12 31.1
    Third trimester 21 0.07 (0.02) 0.06 0.04–0.12 26.8 17 0.10 (0.05) 0.08 0.05–0.20 51.1
    Postpartum 10 0.05 (0.01) 0.05 0.03–0.07 20.2 10 0.14 (0.07) 0.12 0.09–0.34 52.3
Bc
    Second trimester 2 0.08 (0.03) 0.08 0.07–0.10 31.0 1 0.15 0.15 0.15 —
    Third trimester 29 0.10 (0.04) 0.08 0.05–0.27 43.4 9 0.18 (0.05) 0.19 0.06–0.25 30.8
    Postpartum 19 0.17 (0.06) 0.17 0.05–0.27 36.3 8 0.37 (0.19) 0.31 0.18–0.77 51.8
Cb
    Second trimester 20 0.63 (0.63) 0.28 0.06–1.88 99.5 5 0.07 (0.02) 0.08 0.04–0.10 33.4
    Third trimester 24 0.09 (0.03) 0.08 0.03–0.17 34.7 19 0.06 (0.02) 0.05 0.02–0.12 37.0
    Postpartum 9 0.10 (0.05) 0.09 0.06–0.21 50.3 2 0.08 (0.01) 0.08 0.07–0.08 10.7
Db,d
    Second trimester 11 0.15 (0.11) 0.12 0.07–0.46 71.8 7 0.18 (0.04 0.17 0.15–0.24 20.1
    Third trimester 21 0.08 (0.03) 0.07 0.03–0.13 36.3 18 0.23 (0.07) 0.21 0.13–0.39 32.2
    Postpartum 29 0.10 (0.05) 0.09 0.04–0.20 44.4 29 0.25 (0.11) 0.25 0.08–0.50 42.6
Eb,d
    Second trimester 19 0.09 (0.03) 0.08 0.04–0.17 36.8 17 0.17 (0.06) 0.16 0.11–0.30 34.6
    Third trimester 24 0.11 (0.04) 0.10 0.07–0.26 38.4 20 0.12 (0.03) 0.11 0.08–0.20 29.6
    Postpartum 10 0.11 (0.04) 0.12 0.04–0.17 35.4 9 0.24 (0.11) 0.22 0.16–0.51 44.5
Fb
    Second trimester 22 0.10 (0.06) 0.09 0.03–0.29 53.6 16 0.11 (0.05) 0.09 0.05–0.24 45.3
    Third trimester 27 0.09 (0.03) 0.09 0.05–0.20 36.0 13 0.13 (0.05) 0.14 0.03–0.19 39.9
    Postpartum 5 0.08 (0.03) 0.09 0.04–0.11 31.9 1 0.14 0.14 0.14 —
Gb
    Second trimester 11 0.11 (0.04) 0.10 0.06–0.22 36.1 11 0.13 (0.05) 0.14 0.05–0.22 39.6
    Third trimester 28 0.12 (0.04) 0.11 0.07–0.23 32.4 28 0.10 (0.06) 0.09 0.04–0.27 53.8
    Postpartum 8 0.08 (0.03) 0.07 0.06–0.14 32.3 4 0.09 (0.01) 0.09 0.08–0.11 13.9
Hb,d
    Second trimester 19 0.09 (0.03) 0.08 0.04–0.14 31.5 16 0.16 (0.04) 0.17 0.10–0.27 24.2
    Third trimester 33 0.08 (0.02) 0.08 0.04–0.15 29.6 30 0.18 (0.05) 0.19 0.08–0.32 29.2
    Postpartum 16 0.12 (0.05) 0.11 0.06–0.25 43.7 14 0.30 (0.12) 0.33 0.14–0.59 39.5
Ic
    Second trimester 3 0.08 (0.03) 0.07 0.06–0.12 41.2 3 0.09 (0.03) 0.10 0.05–0.11 38.6
    Third trimester 36 0.08 (0.02) 0.08 0.03–0.15 28.9 12 0.08 (0.04) 0.09 0.03–0.14 43.1
    Postpartum 1 0.07 0.07 0.07 — 0 — — — —
All
    Second trimester 113 0.19 (0.33) 0.10 0.03–1.88 171.8 80 0.14 (0.06) 0.14 0.04–0.30 40.8
    Third trimester 243 0.09 (0.04) 0.08 0.03–0.27 39.2 166 0.13 (0.07) 0.13 0.02–0.39 54.0
    Postpartum 107 0.11 (0.05) 0.09 0.03–0.27 50.0 77 0.25 (0.14) 0.21 0.07–0.77 55.5
a

RSD, relative standard deviation.

b

Intrasubject variation in BUP-Gluc:NBUP-Gluc ratios across trimesters evaluated with Kruskal–Wallis tests with Dunn multiple comparison test as a post-hoc analysis. At P < 0.05, the following statistically significant differences were identified: participants A and G, third trimester > postpartum; participants C and D, second trimester < third trimester; participant B, second trimester < postpartum; participant H, third trimester < postpartum.

c

Intrasubject variation not evaluated for BUP-Gluc:NBUP-Gluc or NBUP:NBUP-Gluc because n < 5 for 1 or more time periods.

d

Intrasubject variation in NBUP:NBUP-Gluc ratios across trimesters evaluated with Kruskal–Wallis tests with Dunn multiple comparison test as a post-hoc analysis. At P < 0.05, the following statistically significant differences were identified: participant E, second trimester < third trimester and third trimester < postpartum; participant H, second and third trimesters < postpartum.