. Author manuscript; available in PMC: 2011 Sep 3.

Published in final edited form as: Toxicol Pathol. 2009 Dec 17;38(1):188–197. doi: 10.1177/0192623309356452

Table 2.

Percentage of rodent carcinogens that target the gastrointestinal tract in NTP studies^a and CPDB.^b

Source of data	Target organ	Number and percentage of rodent carcinogens
NTP^a	Stomach	36/290^c (12%)
	Intestines	19/290 (7%)
CPDB^b (Rat)	Stomach	88/564^d (15%)
	Small intestine	29/564 (5%)
	Large intestine	32/564 (6%)
CPDB^b (Mouse)	Stomach	69/442 (16%)
	Small intestine	6/442 (1.4%)
	Large intestine	3/442 (1%)

Out of over 570 chronic studies conducted by the NTP (http://ntp.niehs.nih.gov/).

Data obtained from the Carcinogenic Potency Database (CPDB). The numbers of chemicals that are listed as carcinogenic to the intestines were obtained from a comprehensive table listing frequency of target organs for 564 carcinogens in rats and 442 carcinogens in mice. (http://potency.berkeley.edu/). Many chemicals induce tumors at more than one site, and these are counted at each relevant target site.

Rodent carcinogens were those classified as some or clear evidence of carcinogenic activity or positive in NTP studies.

Rodent carcinogens were identified by CPDB criteria.