Table 3.

Effect of des-acyl ghrelin on food intake in rodents.

Site of administration	Dose (μg/kg)	Feeding condition	Circadian phase	Species	Effect on food intake	Reference
icv	1.9	ad lib	light, dark	rats	↑	[146]
icv	9.1–91	ad lib	light	mice	=	[9]
icv	91	fasted	light	mice	↓	[9]
iv	14.4–48	ad lib	light	rats	=	[146]
ip	128	ad lib	light	mice	=	[146]
ip	274	fasted	light	mice	↓	[9]
ip	64	ad lib	light	rats	=	[31]
ip	64	fasted	light	rats	↓	[31]
ip	64	ad lib	dark	rats	↓	[31]
ip	960	ad lib, fasted	ns	mice	=	[104]
ip	64–125	ad lib, fasted	light	rats	=	[66]

icv: intracerebroventricular, iv: intravenous, ip: intraperitoneal, ad lib: ad libitum fed, fas: fasted, ns: not specified