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. 2011 Jul;13(4):343–351. doi: 10.1111/j.1525-142X.2011.00489.x

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Copyright © 2011 Wiley Periodicals, Inc.

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Fig. 3 — Alx expression in the developing head of mouse, chick, and frog embryos. Expression of mouse, chick, and Xenopus Alx genes during craniofacial development was compared using whole mount in situ hybridization. Lateral (A, C, E, G, I, K, L, M, N) and frontal (B, D, F, H, J) views of the developing head are shown. At E10.5-11 in mouse, Alx1 (A, B), Alx3 (C, D), and Alx4 (E, F) are expressed in the mesenchyme of the facial prominences, particularly around the nasal region (n), and at the distal tip of the mandible (md). At this stage, Alx3 is additionally expressed in the mesenchyme (C, white arrow) encircling the eye. (). At stages 22–24 of chick development, Alx1 (G, H) and Alx4 (I, J) are also expressed in the facial prominences, again with strong expression around the nasal region (n), and at the distal tip of the mandible (md). In the chick, however, both Alx1 (G) and Alx4 (I) are expressed in the periocular mesenchyme (white arrows). Periocular expression of Alx1 is observed in frog embryos at the stage of 24 (K, white arrow). At this stage, Alx4 is not expressed in frog embryos (M) but later at stage 35, both Alx1 (L) and Alx4 (N) are expressed in frontal mesenchyme above the cement gland (cg).

Inline graphic — Alx expression in the developing head of mouse, chick, and frog embryos. Expression of mouse, chick, and Xenopus Alx genes during craniofacial development was compared using whole mount in situ hybridization. Lateral (A, C, E, G, I, K, L, M, N) and frontal (B, D, F, H, J) views of the developing head are shown. At E10.5-11 in mouse, Alx1 (A, B), Alx3 (C, D), and Alx4 (E, F) are expressed in the mesenchyme of the facial prominences, particularly around the nasal region (n), and at the distal tip of the mandible (md). At this stage, Alx3 is additionally expressed in the mesenchyme (C, white arrow) encircling the eye. (). At stages 22–24 of chick development, Alx1 (G, H) and Alx4 (I, J) are also expressed in the facial prominences, again with strong expression around the nasal region (n), and at the distal tip of the mandible (md). In the chick, however, both Alx1 (G) and Alx4 (I) are expressed in the periocular mesenchyme (white arrows). Periocular expression of Alx1 is observed in frog embryos at the stage of 24 (K, white arrow). At this stage, Alx4 is not expressed in frog embryos (M) but later at stage 35, both Alx1 (L) and Alx4 (N) are expressed in frontal mesenchyme above the cement gland (cg).