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. 2011 Aug 18;5(3):395–396. doi: 10.5009/gnl.2011.5.3.395

Hepatitis A in Developed Country, the Result Should Interpret Carefully

Seyed-Moayed Alavian 1,
PMCID: PMC3166686  PMID: 21927674

Dear Editor,

I read with interest the published article by Chung et al.1 recently in your journal. Hepatitis A virus (HAV) infection continues to be a major health problem worldwide. Prevalence of HAV infection differs greatly in various parts of the world according to the geographic area, sanitary conditions and socioeconomic levels.2 As the authors presented the prevalence rate for anti-HAV Ab increased significantly, studies in various communities have shown that HAV prevalence rises with age.3 It will emphasize the need anti HAV vaccine during childhood in Korea especially when the symptomatic HAV infections have remarkably reported in Korea been increased during recent years.4 But there are some points that can help the readers for better understanding the issue. The living place of study group was urban and it may under-estimate the real prevalence of anti-HAV Ab in general population in Korea. In changing the developing countries to developed countries, the improvement in health status in not uniform and there are heterogeneity in distribution in every country.5 These limitation prevent for final conclusion regarding all of country in Korea, however the result is very important for health policy makers for any decision in future.

Footnotes

No potential conflict of interest relevant to this article was reported.

References

  • 1.Chung GE, Yim JY, Kim D, et al. Seroprevalence of hepatitis a and associated socioeconomic factors in young healthy Korean adults. Gut Liver. 2011;5:88–92. doi: 10.5009/gnl.2011.5.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Alavian SM. Hepatitis A. Aust Fam Physician. 2011;40:185. [PubMed] [Google Scholar]
  • 3.Sofian M, Aghakhani A, Farazi AA, et al. Seroepidemiology of hepatitis A virus in children of different age groups in Tehran, Iran: implications for health policy. Travel Med Infect Dis. 2010;8:176–179. doi: 10.1016/j.tmaid.2010.02.004. [DOI] [PubMed] [Google Scholar]
  • 4.Lee D, Cho YA, Park Y, et al. Hepatitis a in Korea: epidemiological shift and call for vaccine strategy. Intervirology. 2008;51:70–74. doi: 10.1159/000127428. [DOI] [PubMed] [Google Scholar]
  • 5.Saberifiroozi M. Hepatitis A virus infection: Is it an important hazard to public health? Hepat Mon. 2011;11:235–237. [PMC free article] [PubMed] [Google Scholar]
Gut Liver. 2011 Aug 18;5(3):395–396.

Reply to the Letter to the Editor: Hepatitis A in Developed Country, the Result Should Interpret Carefully

Goh Eun Chung 1, Jeong Yoon Yim 1,, Donghee Kim 1, Seon Hee Lim 1, Min Jung Park 1, Young Sun Kim 1, Sun Young Yang 1, Jong In Yang 1, Sang-Heon Cho 1

The decreasing tendency of seropositivity of hepatitis A virus (HAV) in young healthy Korean adults was observed in our study1 and this epidemiological shift was shown in changing the developing countries to developed countries.2-4 The point that we suggest was the catch-up vaccination for young adults especially 20s who have only 6.2% of HAV seropositivity because they are vulnerable to severe symptomatic infection. Also, the prevalence of HAV antibody was lower in high income group and the H. pylori-negative group among young adults (<50 aged), the groups are also considerable to candidates to screening for protective antibodies against HAV and vaccination because the mortality rate of hepatitis A becomes higher at older age.5 However, the improvement in health status is not uniform in the same country and the seroprevalence can be heterogeneity in distribution. Although the living place of subjects was not exactly evaluated in this study, most our subjects were collected in urban and high income group was relatively a large portion as we have already mentioned as a limitation of our study. It may underestimate the real prevalence of seroprevalence of HAV in general young population in Korea. According to a recent study based on the latest nationwide survey in Korea,6 the persons in their 20s in 2009 were found to be the most vulnerable to the infection of HAV with the lowest antibody positive rates (10.4% to 13.3%) regarding all of country evaluated including rural area. Thus, catch-up vaccination for young adults with a low antibody positive rated is to be considered in Korea. However, health policy in every country should be individualized.

Footnotes

No potential conflict of interest relevant to this article was reported.

References

  • 1.Chung GE, Yim JY, Kim D, et al. Seroprevalence of hepatitis a and associated socioeconomic factors in young healthy Korean adults. Gut Liver. 2011;5:88–92. doi: 10.5009/gnl.2011.5.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Tsai CF, Lin DB, Chen SC, Chang YH, Chen CY, Lin JB. Seroepidemiology of hepatitis A virus infection among schoolchildren in Taiwan. J Med Virol. 2011;83:196–200. doi: 10.1002/jmv.22000. [DOI] [PubMed] [Google Scholar]
  • 3.Kremastinou J, Kalapothaki V, Trichopoulos D. The changing epidemiologic pattern of hepatitis A infection in urban Greece. Am J Epidemiol. 1984;120:703–706. doi: 10.1093/oxfordjournals.aje.a113937. [DOI] [PubMed] [Google Scholar]
  • 4.Amela C, Pachón I, Bueno R, de Miguel C, Martinez-Navarro F. Trends in hepatitis A virus infection with reference to the process of urbanization in the greater Madrid area (Spain) Eur J Epidemiol. 1995;11:569–573. doi: 10.1007/BF01719310. [DOI] [PubMed] [Google Scholar]
  • 5.Kim JI, Kim YS, Jung YK, et al. Factors influencing the severity of acute viral hepatitis A. Korean J Hepatol. 2010;16:295–300. doi: 10.3350/kjhep.2010.16.3.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Lee D, Ki M, Lee A, et al. Nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates. Korean J Hepatol. 2011;17:44–50. doi: 10.3350/kjhep.2011.17.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut and Liver are provided here courtesy of The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Society of Pancreatobiliary Disease, and the Korean Society of Gastrointestinal Cancer

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