Table 6.

Clinical studies of the use of [¹⁸F]FLT for monitoring therapy response

Tumour type	Therapy	Change in FLT uptake with therapy	Reference
Lung	Gefitinib	Reduction after 7 days; correlated with response	Sohn et al., 2008
	Chemo/radiotherapy	Reduction at day 2, 8 and 29	Everitt et al., 2009
Gliomas	Bevacizumab and irinotecan	Reduction at 6 weeks; correlation with progression-free survival	Chen et al., 2007
	Temozolamide	Correlation with tumour response	Galldiks et al., 2010
Germ cell tumours	Combination chemotherapy	Reduction; no association with response	Pfannenberg et al., 2010
Non-Hodgkin's lymphoma	CHOP, R-CHOP, rituximab	Reduction after 2 days; correlated with response. No change with rituximab	Herrmann et al., 2007
Breast cancer	Various chemotherapy and hormone therapy	Reduction at 2 weeks; correlated with response	Pio et al., 2006
	Combination 5-FU, epirubicin, cyclophosphamide	Reduction at 1 week; correlated with response	Kenny et al., 2007
Colorectal	Combination 5-FU and radiotherapy	Reduction at 2 weeks; no correlation with response	Wieder et al., 2007
Oropharyngeal cancer	Radiotherapy	Reduction at 1 week	Troost et al., 2010
	Radiotherapy	Increase 2–3 months compared with baseline; correlation with presence of disease	Been et al., 2009
Melanoma	CTLA4 blockade	No change in tumour uptake	Ribas et al., 2010
Colon (COLO205 cells)	Checkpoint kinase 1 (Chk1)inhibitor and docetaxel	Reduction with docetaxel and combination treatment at day 2 + 16	Zhang et al., 2009