Figure 1.

The effect of sauchinone (Sau) on acetaminophen (APAP)-induced liver injury. Male wild-type (WT) or Nrf2 knockout mice that had been treated with Sau (30 mg·kg⁻¹·day⁻¹, p.o., for 3 days) were administered a single dose of APAP (500 mg·kg⁻¹, i.p.). The animals were killed 6 h after APAP treatment. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were measured in the plasma samples. N.S., not significant.