Table 1.

Parameters for the model of cardiac uptake and metabolism kinetics of ebastine and formation of hydroxyebastine and carebastine, respectively, estimated in an rat isolated heart preparation

Parameter (h−1)	Uptake		Metabolism
Ebastine	kin,e	kout,e	keh
	16.3 (16)	0.846 (32)	0.834 (9)
Hydroxyebastine	kin,h	kout,h	khc
	0.067 (7)	0.307 (49)	4.82 (22)
Carebastine	kin,c	kout,c	kcm
	13.7 (28)	492 (17)	1.31 (5)

Mean values and inter-individual variability as relative standard error (%) in brackets, n = 6.