Table 4.
Relative Risk of Incident Breast Cancer, by Quintile of Dietary Approaches to Stop Hypertension Score, Nurses’ Health Study, 1980–2006
| Type of Cancer | Quintile 1 | Quintile 2 | 95% CI | Quintile 3 | 95% CI | Quintile 4 | 95% CI | Quintile 5 | 95% CI | P Trend |
| Total breast cancer | ||||||||||
| No. of cases | 975 | 1,009 | 1,125 | 1,147 | 1,266 | |||||
| Age- and energy-adjusted analyses | 1 | 0.92 | 0.84, 1.00 | 0.97 | 0.89, 1.06 | 0.97 | 0.89, 1.06 | 0.97 | 0.89, 1.05 | 0.71 |
| Multivariate analysisa | 1 | 0.90 | 0.82, 0.99 | 0.95 | 0.87, 1.04 | 0.95 | 0.87, 1.04 | 0.97 | 0.89, 1.06 | 0.98 |
| Estrogen receptor-positive tumors | ||||||||||
| No. of cases | 573 | 605 | 673 | 715 | 752 | |||||
| Age- and energy-adjusted analyses | 1 | 0.94 | 0.84, 1.06 | 0.99 | 0.88, 1.11 | 1.03 | 0.92, 1.15 | 0.98 | 0.87, 1.09 | 0.87 |
| Multivariate analysisa | 1 | 0.91 | 0.81, 1.02 | 0.95 | 0.84, 1.06 | 0.98 | 0.88, 1.10 | 0.96 | 0.85, 1.08 | 0.89 |
| Estrogen receptor-negative tumors | ||||||||||
| No. of cases | 166 | 162 | 162 | 156 | 181 | |||||
| Age- and energy-adjusted analyses | 1 | 0.87 | 0.70, 1.08 | 0.82 | 0.66, 1.02 | 0.80 | 0.64, 1.00 | 0.83 | 0.66, 1.02 | 0.03 |
| Multivariate analysisa | 1 | 0.85 | 0.68, 1.06 | 0.80 | 0.64, 1.00 | 0.77 | 0.61, 0.97 | 0.80 | 0.64, 1.01 | 0.02 |
Abbreviation: CI, confidence interval.
Adjusted for age, energy intake, multivitamin use, smoking, body mass index, height, weight at 18 years of age, weight change since 18 years of age, family history of breast cancer, benign breast disease, physical activity level, alcohol intake, and menopausal hormone use.