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Splicing coactivator model for the function of SRm160/300. SRm160/300 promotes splice-site pairing and splicing through multiple cooperative interactions with factors bound to pre-mRNA, including SR family proteins U1 and U2 snRNPs. A role for the RS domains of these factors in mediating an intron-wide network of interactions is emphasized. These early interactions are required for the splicing of specific pre-mRNAs. (BS) Branch site; [(Py)n] polypyrimidine tract; (SS) splice site.
