Table 4.

Progression rates and Univariate and Multivariate Hazard Ratios for Progression (n=950)

	Progression events /100py [95% CI]	Univariate Hazard Ratio [95% CI]	Multivariate Hazards Ratio [95% CI]
Age in years
18-25	13.6 [10.3 – 17.9]	REF	REF
26-35	12.1 [10.3 – 14.2]	0.86 [0.62 – 1.18]	0.86 [0.62 – 1.18]
36-45	9.4 [7.2 – 12.3]	0.68 [0.46 – 1.00]	0.68 [0.46 – 1.01]
>45	12.1 [7.3 – 20.0]	0.89 [0.50 – 1.58]	0.83 [0.46 – 1.49]
Baseline CD4 Count
<200	12.8 [10.3 – 16.0]	1.54 [1.09 – 2.19]*	1.96 [1.33 – 2.88]***
200-350	13.2 [10.5 – 16.4]	1.69 [1.19 – 2.42]**	1.90 [1.32 – 2.73]***
351-500	12.9 [10.2 – 16.4]	1.62 [1.12 – 2.34]**	1.65 [1.14 – 2.39]**
>500	8.1 [6.1 – 10.7]	REF	REF
Baseline Smear Result
Normal	12.3 [10.9 – 14.1]	REF	REF
LSIL	9.2 [6.9 – 12.3]	0.79 [0.57 – 1.09]	0.73 [0.53 – 1.02]
HAART Status
On HAART	11.4 [8.9 – 14.5]	0.86 [0.65 – 1.13]	0.72 [0.52 – 0.99]*
Not on HAART	11.8 [10.3 – 13.5]	REF	REF
Smoking Exposure
Ever Smoker	13.4 [10.2 – 17.8]	1.16 [0.85 – 1.58]	1.13 [0.83 – 1.54]
Never Smoker	11.4 [10.0 – 12.9]	REF	REF
Baseline Weight (kg)
Bottom Tertile (34.0 – 59.0 kgs)	12.2 [9.9 – 15.0]	REF	--
Middle Tertile (59.1 – 72.3 kgs)	12.0 [9.8 – 14.7]	1.07 [0.80 – 1.42]	--
Upper Tertile (72.4 – 153.0 kgs)	11.0 [8.9 – 13.4]	1.03 [0.77 – 1.37]	--

^*p≤0.05;

^**p≤0.01;

^***p≤0.001

LSIL – low grade squamous intraepithelial lesion; HAART – highly active antiretroviral therapy