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Housing of the experimental animals. Female C57Bl/6 mice (n = 10 per group) were housed in large cages (30″ × 33″ × 8″) as shown. (A) Control (CON). (B) Running (RUN); cage with 10 running wheels for voluntary physical activity. (C) Enriched environment only (EEO). (D) Enrichment and running (EER); the cage contained enrichment objects similar to C, as well as 10 running wheels. (E) Overview of the experimental cages.
