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. 1998 Apr 1;12(7):982–995. doi: 10.1101/gad.12.7.982

Figure 4.

Figure 4

Figure 4

Figure 4

 MEFs lacking CHOP’s major dimerization partner, C/EBPβ, are also resistant to the death-promoting effects of tunicamycin. (A) Photomicrograph (300×) of MEFs with the indicated c/ebpβ genotype 24 hr after treatment with tunicamycin (1 μg/ml). (B) Nuclear morphology of the same cells fixed and stained with the DNA-binding dye H33258. Note the increased fraction of cells with condensed chromatin in the c/ebpβ +/− population. (C) Quantification of the fraction of dead cells as a function of time in the two populations, analyzed as in Fig. 2C. (D) Intact CHOP response to tunicamycin in the c/ebpβ mutant cells. Shown is a Western blot of CHOP and TLS (the internal control) in untreated and tunicamycin-treated cells with the indicated genotypes.