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. 2011 May 16;193(4):655–665. doi: 10.1083/jcb.201011038

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© 2011 Vega et al.

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Figure 5. — RhoC acts through FMNL3 to regulate cell shape and invasion. (A) F-actin in PC3 cells after transfection with indicated siRNAs. Bar, 20 µm. (B) Transwell invasion assay with PC3 cells; invasion is relative to siControl. (C) GST-RhoA/C-V14 pull-down with lysates from 293T cells expressing GFP-FMNL3. MW, molecular weight markers. (D) F-actin and GFP localization in PC3 cells transfected with the indicated siRNAs and either GFP-FMNL3 or GFP alone. White asterisks indicate GFP-FMNL3 cells. The graph on the right shows quantification of GFP-positive cells with broad lamellipodia; *, P < 0.05. Error bars indicate mean ± SEM.