Table I.
Comparison of NPC and shuttling proteins identified from LC-MS/MS studies
| Type | Down-regulated by HIV-1 | Up-regulated by HIV-1 | ||
| This study (purified NEs) | Chan et al.a (whole cells) | This study (purified NEs) | Chan et al.a (whole cells) | |
| Nups (54%)b | KTN1, NUP43, NUP58, NUP45, NUP54, GP210, POM121, NUP107, NUP133, NUP155, NUP160, NUP37, NUP85, NUP93 | KTN1, NUP43, NUP58/NUP45, NUP54, NUP50, NUP62 | NUP35, NUP98, TPR | NUP35, NUP98, TPR, NUP153, NUP214, NUP93, POM121 |
| Importins (100%) | KNPB1, KPNA2 | KPNB1, KPNA2, KPNA3, KPNA4, KPNA6, IPO5, IPO7, IPO9, TNPO1, TNPO2, TNPO3 | N/D | KPNA1 |
| Ran GTP–GDP cycle (100%) | RANGAP1, RCC1 | RANBP2(NUP358), RANGAP1, RCC1, NUTF2, RANBP1, RANBP3, RAP1GDS1, SUMO1 | N/D | RAN, RAE1 |
| Exportins | RIP | N/D | NXF1 | RIP, XPO1, XPO2, XPO5, XPO7 |
| hnRNP proteins (50%) | HNRNPG, HNRNPK, HNRNPL, HNRNPR | HNRNPG, HNRNPF | HNRNPA1, HNRNPA2, HNRNPC, HNRNPM, HNRNPU | HNRNPA1, HNRNPA2, HNRNPC, HNRNPM, HNRNPU, HNRNPH, HNRNPK, HNRNPL, HNRNPQ, HNRNPR |
Boldface text indicates common proteins between studies that are modulated in a similar direction by HIV-1. Italicized proteins were found to be regulated in an opposite manner. N/D, not detected.
a
Mass spectrometry hits found in Chan et al. (2007) and/or Chan et al. (2009).
b
Quantitative correspondence between this study and those of Chan et al. (2007, 2009).