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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Curr Opin Struct Biol. 2011 Jul 21;21(4):567–572. doi: 10.1016/j.sbi.2011.06.011

Figure 1.

Figure 1

Agonist-β2AR-T4L-Nb80 complex in crystals formed in lipidic cubic phase [45••]. (a) Two different views of the crystal packing: β2AR indicated in orange and Nb80 in blue. The β2AR-nanobody complexes are arranged with the lipid bilayers approximately parallel to the bc plane of the crystal. Twofold symmetry related nanobody molecules interact along the a axis to generate a tightly packed lattice in this direction. (b) Nb80 binds to the cytoplasmic end of the β2AR, with the third complementarity determining region loop (CDR3) projecting 14Å into the core of the receptor.