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. 2000 Jun 15;14(12):1498–1511.

Figure 9.

Figure 9

SNS expression in the putative fusion competent cells is dependent on Notch. Wild-type and NXK11 mutant embryos were analyzed for expression of SNS and the founder cell marker VG (Williams et al. 1991). SNS expression is indicated in red (A,B,D,E), and VG expression is indicated in green (B,C,E,F). Both embryos are at Stage 13, and all views are ventral with anterior to the left. (A–C) Confocal projections of 22 × 1 micron sections of a wild-type embryo. As expected, both SNS- and VG-expressing cells are seen. (D–F) Confocal projections of 16 × 1 micron sections through an NXK11 mutant embryo at the same stage. As expected, the Notch mutant embryo exhibits a dramatically expanded population of VG-expressing founder cells compared to wild-type (compare B and C with E and F). By contrast, SNS expression is dramatically decreased (compare A and B with D and E), presumably due to the absence of fusion competent cells.