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. 2011 Aug 16;18(1):57. doi: 10.1186/1423-0127-18-57

Figure 4.

Figure 4

Improvement of GSIS by Insig-1 overexpression. INS-1 and INS-1-Insig-1 cells were cultured in RPMI 1640 with different glucose concentrations for 0, 24 and 72 h, medium were then changed to KRBH containing 3 mM and 20 mM glucose and then collected for basal and glucose stimulated insulin secretion. Insulin concentration was determined by rat insulin RIA. * P < 0.05; ** P < 0.01 VS exposed to 11.2 mM glucose at the same time point; # P < 0.05 VS INS-1 cells exposed to 25.0 mM glucose at the same time point.