Table 2.
Top Candidate SNPs from the Ashkenazi Jewish, NINDS and CIDR/Pankratz et al 2009 Datasets
| Ashkenazi Jewish | NINDS | CIDR/Pankratz et al 2009 | Meta-analysis | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | CHR | BP | A1 | GENE | F_A | P | OR | F_A | P | OR | F_A | P | OR | A2 | Z | P | Direction |
| F_U | 95% CI | F_U | 95% CI | F_U | 95% CI | score | |||||||||||
| rs1694037 | 3 | 21941114 | T | LOC10055836 | 0.096 | 1.02 × 10-5 | 0.42 | 0.097 | 0.849 | 1.02 | 0.121 | 0.049 | 1.24 | T | -1.3 | 0.193 | - ++ |
| 0.199 | 0.29-0.62 | 0.095 | 0.81-1.28 | 0.100 | 1.00-1.54 | ||||||||||||
| rs4976493 | 5 | 135210022 | A | SLC25A48 | 0.442 | 6.66 × 10-5 | 1.77 | 0.403 | 0.026 | 1.17 | 0.367 | 0.190 | 0.91 | A | 2.8 | 0.005 | ++- |
| 0.309 | 1.34-2.35 | 0.366 | 1.02-1.34 | 0.389 | 0.79-1.05 | ||||||||||||
| rs10121009 | 9 | 35259819 | A | UNC13B | 0.131 | 5.32 × 10-5 | 0.49 | 0.182 | 0.045 | 0.84 | 0.185 | 0.032 | 0.83 | A | -4.7 | 2.75 × 10-6 | - - - |
| 0.235 | 0.34-0.69 | 0.209 | 0.71-1.00 | 0.214 | 0.70-0.98 | ||||||||||||
| rs4745122* | 9 | 73582507 | A | Intergenic | 0.351 | 5.48 × 10-5 | 1.87 | 0.243 | 0.007 | 1.25 | 0.234 | 0.748 | 0.97 | A | 3.7 | 2.15 × 10-4 | ++- |
| 0.225 | 1.38-2.54 | 0.205 | 1.06-1.47 | 0.239 | 0.83-1.14 | ||||||||||||
| rs7171137 | 15 | 90363631 | A | SLCO3A1 | 0.397 | 3.79 × 10-5 | 1.84 | 0.370 | 0.013 | 1.20 | 0.351 | 0.620 | 1.04 | A | 4.1 | 4.09 × 10-5 | +++ |
| 0.264 | 1.38-2.47 | 0.330 | 1.04-1.38 | 0.343 | 0.90-1.19 | ||||||||||||
| rs183211 | 17 | 42143493 | T | NSF | 0.207 | 7.16 × 10-5 | 0.54 | 0.213 | 0.102 | 0.87 | 0.196 | 0.001 | 0.77 | T | -5.1 | 2.80 × 10-7 | - - - |
| 0.326 | 0.40-0.73 | 0.236 | 0.75-1.03 | 0.241 | 0.65-0.90 | ||||||||||||
| rs415430 | 17 | 42214305 | C | WNT3 | 0.202 | 8.45 × 10-5 | 0.54 | 0.173 | 0.002 | 0.77 | C | -5.0 | 6.87 × 10-7 | -- | |||
| -- | 0.317 | 0.40-0.74 | 0.214 | 0.65-0.91 | |||||||||||||
A1: Minor allele, A2: Associated allele, F_A: Minor allele freq. of case, F_U: Minor allele freq. of control, OR: odds ratios, 95% CI: 95% confidence interval, * rs4745122 is located ~8.9Kb proximal to TMEM2.