Table 3.
MAPT | NSF | WNT3 | Ashkenazi Jewish | NINDS | CIDR/Pankratz et al 2009 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Single point | rs1981997 | rs183211 | rs415430 | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI |
A | 0.0009118 | 0.58 | 0.42-0.90 | 0.07504 | 0.86 | 0.73-1.01 | 0.0001569 | 0.72 | 0.61-0.86 | |||
T | 6.68 × 10-5 | 0.54 | 0.40-0.73 | 0.1015 | 0.87 | 0.74-1.02 | 0.001375 | 0.77 | 0.65-0.90 | |||
C | 8.59 × 10-5 | 0.54 | 0.30-0.74 | 0.002397 | 0.77 | 0.65-0.91 | N/A | |||||
2-mer | rs1981997 | rs183211 | rs415430 | P-value | Freq. Cases | Freq. Controls | P-value | Freq. Cases | Freq. Controls | P-value | Freq. Cases | Freq. Controls |
G | C | 0.00034 | 0.7743 | 0.6657 | 0.2634 | 0.7654 | 0.7491 | 0.0003 | 0.791 | 0.7386 | ||
A | C | 0.2118 | 0.0187 | 0.0084 | 0.1986 | 0.0217 | 0.0157 | 0.1059 | 0.0128 | 0.0198 | ||
G | T | 0.3211 | 0.0466 | 0.0618 | 0.2344 | 0.0444 | 0.0364 | 0.9238 | 0.0326 | 0.0332 | ||
A | T | 0.00016 | 0.1604 | 0.264 | 0.0214 | 0.1685 | 0.1989 | 0.0007 | 0.1636 | 0.2084 | ||
T | C | 0.00023 | 0.1559 | 0.2558 | 0.0145 | 0.1647 | 0.1967 | |||||
C | C | 0.2912 | 0.0456 | 0.0617 | 0.0191 | 0.0081 | 0.0169 | |||||
T | T | 0.2408 | 0.0512 | 0.0701 | 0.2133 | 0.0482 | 0.0395 | |||||
C | T | 1.91 × 10-5 | 0.7473 | 0.6125 | 0.0269 | 0.7790 | 0.7469 | N/A | ||||
3-mer | A | T | C | 0.00018 | 0.156 | 0.2585 | 0.0133 | 0.1626 | 0.1951 | |||
G | C | C | 0.3544 | 0.0445 | 0.0584 | 0.0134 | 0.0081 | 0.0175 | ||||
G | T | T | 0.2446 | 0.0450 | 0.0628 | 0.2758 | 0.0422 | 0.0350 | ||||
A | C | T | 0.1172 | 0.0194 | 0.0066 | 0.2187 | 0.0222 | 0.0163 | ||||
G | C | T | 0.00014 | 0.7351 | 0.6137 | 0.0518 | 0.7649 | 0.7361 | N/A |
*Adjusted for age and sex. Age refers to age at onset for affected individuals, and age at examination for unaffected individuals. OR: odds ratios, 95% CI: 95% confidence interval; P-values for allelic/haplotype association; Single point shows the protective allele of each SNP; N/A, SNP rs415430 is not available in PD/CIDR data.