Table 2.
Association of ACE, NOD1, TLR4, FAS and FASL gene polymorphisms with gastric cancer and high risk atrophic gastritis
| Genotypes | Controls (n = 238) | GC (n = 114) | HRAG (n = 222) | ||||
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | OR (95% CI) | p | n (%) | OR (95% CI) | p | |
| ACE I/D | |||||||
| I/I | 62 (26.1) | 27 (23.7) | 0.88 (0.52-1.48) | 0.632 | 62 (27.9) | 1.10 (0.73-1.66) | 0.650 |
| I/D | 110 (46.2) | 59 (51.8) | 1.25 (0.79-1.95) | 0.331 | 108 (48.6) | 1.10 (0.76-1.59) | 0.602 |
| D/D | 66 (27.7) | 28 (24.6) | 0.85 (0.51-1.42) | 0.529 | 52 (23.4) | 0.79 (0.52-1.21) | 0.290 |
| Allele I | 234 (49.2) | 113 (49.6) | 1.02 (0.74-1.39) | 0.921 | 232 (52.3) | 1.13 (0.87-1.47) | 0.348 |
| Allele D | 242 (50.8) | 115 (50.4) | 0.98 (0.72-1.35) | 0.921 | 212 (47.7) | 0.88 (0.68-1.15) | 0.348 |
| NOD1 796G>A | |||||||
| G/G | 129 (54.4) | 61 (54.5) | 1.00 (0.64-1.57) | 0.995 | 138 (62.4) | 1.39 (0.96-2.02) | 0.082 |
| G/A | 85 (35.9) | 40 (35.7) | 0.99 (0.62-1.59) | 1.000 | 66 (29.9) | 0.76 (0.52-1.13) | 0.172 |
| A/A | 23 (9.7) | 11 (9.8) | 1.01 (0.48-2.16) | 0.973 | 17 (7.7) | 0.78 (0.40-1.49) | 0.446 |
| Allele G | 343 (72.4) | 162 (72.3) | 0.99 (0.70-1.42) | 0.991 | 342 (77.4) | 1.31 (0.97-1.76) | 0.081 |
| Allele A | 131 (27.6) | 62 (27.7) | 1.00 (0.70-1.73) | 0.991 | 100 (22.6) | 0.77 (0.57-1.03) | 0.081 |
| TLR4 3725G>C | |||||||
| G/G | 190 (80.5) | 90 (79.6) | 0.95 (0.54-1.66) | 0.849 | 181 (82.3) | 1.12 (0.70-1.80) | 0.629 |
| G/C | 41 (17.4) | 21 (18.6) | 1.09 (0.61-1.94) | 0.782 | 33 (15.0) | 0.84 (0.51-1.38) | 0.492 |
| C/C | 5 (2.1) | 2 (1.8) | 0.83 (0.16-4.36) | 0.832 | 6 (2.7) | 1.29 (0.39-4.31) | 0.672 |
| Allele G | 421 (89.2) | 201 (88.9) | 0.97 (0.59-1.62) | 0.919 | 395 (89.8) | 1.06 (0.69-1.62) | 0.776 |
| Allele C | 51 (10.8) | 25 (11.1) | 1.03 (0.62-1.71) | 0.919 | 45 (10.2) | 0.94 (0.62-1.44) | 0.776 |
| FAS 1377G>A | |||||||
| G/G | 197 (82.8) | 95 (83.3) | 1.04 (0.57-1.88) | 0.895 | 178 (80.2) | 0.84 (0.52-1.35) | 0.471 |
| G/A | 40 (16.8) | 18 (15.8) | 0.92 (0.51-1.70) | 0.809 | 41 (18.5) | 1.12 (0.69-1.81) | 0.640 |
| A/A | 1 (0.4) | 1 (0.9) | 2.09 (0.13-33.8) | 0.593 | 3 (1.4) | 3.2 (0.33-31.4) | 0.282 |
| Allele G | 434 (91.2) | 208 (91.2) | 1.00 (0.57-1.75) | 0.981 | 397 (89.4) | 0.82 (0.52-1.27) | 0.366 |
| Allele A | 42 (8.8) | 20 (8.8) | 0.99 (0.56-1.73) | 0.981 | 47 (10.6) | 1.22 (0.79-1.90) | 0.366 |
| FAS 670A>G | |||||||
| A/A | 70 (29.4) | 31 (27.2) | 0.89 (0.54-1.47) | 0.666 | 68 (30.6) | 1.06 (0.71-1.57) | 0.775 |
| A/G | 127 (53.4) | 62 (54.4) | 1.04 (0.66-1.63) | 0.856 | 101 (45.5) | 0.72 (0.51-1.05) | 0.091 |
| G/G | 41 (17.2) | 21 (18.4) | 1.08 (0.60-1.94) | 0.783 | 53 (23.9) | 1.50 (0.95-2.39) | 0.077 |
| Allele A | 267 (56.1) | 124 (54.4) | 0.93 (0.68-1.28) | 0.699 | 237 (53.4) | 0.89 (0.69-1.16) | 0.408 |
| Allele G | 209 (43.9) | 104 (45.6) | 1.07 (0.78-1.47) | 0.699 | 207 (46.6) | 1.12 (0.86-1.44) | 0.408 |
| FASL 844T>C | |||||||
| T/T | 124 (52.1) | 55 (48.2) | 0.86 (0.55-1.34) | 0.498 | 108 (48.6) | 0.87 (0.60-1.25) | 0.459 |
| T/C | 94 (39.5) | 52 (45.6) | 1.28 (0.81-2.01) | 0.275 | 91 (41.0) | 1.06 (0.73-1.54) | 0.743 |
| C/C | 20 (8.4) | 7 (6.1) | 0.71 (0.29-1.73) | 0.455 | 23 (10.4) | 1.26 (0.67-2.36) | 0.471 |
| Allele T | 342 (71.8) | 162 (71.1) | 0.96 (0.67-1.36) | 0.826 | 307 (69.1) | 0.87 (0.66-1.17) | 0.368 |
| Allele C | 134 (28.2) | 66 (28.9) | 1.04 (0.73-1.47) | 0.826 | 137 (30.9) | 1.14 (0.86-1.51) | 0.368 |
GC, gastric cancer; HRAG, high risk atrophic gastritis, CI, confidence interval; OR, odds ratio The ORs were calculated comparing each genotype vs. the other two genotypes, the first line for each gene polymorphism represents the dominant model and third line represents the recessive model.