Table 3.
Distribution of NOD1 and TLR4 gene polymorphisms in Helicobacter pylori positive and negative subjects
| Genotypes | Hp negative | Hp positive | ||
|---|---|---|---|---|
| n (%) | n (%) | OR (95% CI) | p | |
| NOD1 796G>A | ||||
| G/G | 133 (57.8) | 195 (57.4) | 0.98 (0.69-1.37) | 0.910 |
| G/A | 75 (32.6) | 116 (34.1) | 1.07 (0.75-1.52) | 0.708 |
| A/A | 22 (9.60) | 29 (8.50) | 0.88 (0.49-1.57) | 0.670 |
| Allele G | 341 (74.1) | 506 (74.4) | 1.01 (0.77-1.33) | 0.915 |
| Allele A | 119 (25.9) | 174 (25.6) | 0.98 (0.75-1.29) | 0.915 |
| TLR4 3725G>C | ||||
| G/G | 182 (79.1) | 279 (82.3) | 1.22 (0.80-1.87) | 0.343 |
| G/C | 44 (19.1) | 51 (15.0) | 0.74 (0.48-1.16) | 0.199 |
| C/C | 4 (1.8) | 9 (2.7) | 1.54 (0.46-5.06) | 0.549 |
| Allele G | 408 (88.7) | 609 (89.8) | 1.12 (0.76-1.64) | 0.545 |
| Allele C | 52 (11.3) | 69 (10.2) | 0.88 (0.60-1.30) | 0.545 |
Hp, Helicobacter pylori; OR, odds ratio
The ORs were calculated comparing each genotype vs. the other two genotypes, the first line for each gene polymorphism represents the dominant model and third line represents the recessive model.